Hepatoprotective activity of aeschynomene aspera linn. The rats were divided into four groups, each group consisting of six animals. Terminalia arjuna, stem bark, flavonoids, hepatoprotective activity. Evaluation of the hepatoprotective activity of fagonia. Hepatoprotective activity of methanol extract of some. The hepatoprotective and antioxidant activity of silymarin is caused by its ability to inhibit the free. The present study reports the investigation done on the hepatoprotective activity of ethanolic extract of mikania scandens l. Oct 25, 2019 lycopene hepatoprotective pdf bisphenol a bpaan endocrine disruptor xenoestrogenis widely spread in the environment. The hepatoprotective activity, which is seen at the highest concentration 10 mlkg of vcos used, was also accompanied by the vcos ability to reduce pcminduced increase in body and. Group one was kept on normal diet and served as control, the second.
Phytochemical studies and hepatoprotective activity of melia. The present study aimed to determine the hepatoprotective activity of a methanol extract of melastoma malabathricum leaves memm using two established rat models. Ten groups of rats n 6 were given a oncedaily administration of 10% dimethyl sulfoxide negative control, 200 mgkg silymarin positive control, or memm 50, 250, or 500 mgkg for 7 days followed by induction of. In addition, hepatospecific serum markers will be disturbed. This plant contains at least seven flavoligands and the flavonoid taxifolin. A major project report on evaluation of hepatoprotective activity of amoora rohituka submitted to rajiv gandhi proudyogiki. Medicinal and aromatic plants research institute mapri, national center for research, khartoum, sudan. The principle depends on the fact that administration of acetaminophen will be associated with development of oxidative stress. Among the medicinal plants, myrtus communis family. The effects observed were compared with a known hepatoprotective. Evaluation of hepatoprotective and antioxidant activity of. Hepatoprotective activity of polygala elongata against. Glucoselowering, hepatoprotective and hypolipidemic.
Three new sesquiterpenes and two new rutinosides 4 and 5 along with 17 known compounds 622 were isolated from the leaves of murraya koenigii l. This antioxidant activity is manifested by free radical scavenging 9 10, which can confer a hepatoprotective effect 7 8 11. Malvaceae was examined for its hepatoprotective activity against liver damage induced by acetaminophen in rats. This is the first report of the hepatoprotective activity of the plant. To investigate the hepatoprotective activity of ethanol extract of pavetta indica linn leaves. Hepatoprotective activity of pien tze huang gan bao in ccl 4induced chronic liver injury models jinyan zhao 1,2, daxin chen, shan lin 1,2, yuchen zhang, yun wan, zhenfeng hong1. Hepatoprotective activity of methanol extract of melastoma. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats find, read and cite all the.
The test material was found effective as hepatoprotective. Keeping this in view, the present study has been undertaken to investigate hepatoprotective activity and antioxidant role of the chloroform and. Dill anethum graveolens is an annual herb in the celery family apiaceae. Hepatoprotective potentials of aqueous extract of convolvulus. Galn and lipopolysaccharide lps induced hepatitis in mice. Hepatoprotective activity of sachharum officinarum against paracetamol induced hepatotoxicity in rats. Hepatoprotective activity of parmelia perlata huds. Hepatoprotective activity of some indigenous plants. Bacteria associated with the red sea sponge amphimedon ochracea in ccl 4 induced hepatotoxicty in rats.
Hepatoprotective activity, convolvulus pluricaulis, thioacetamide, alt, ast and bilirubin. On account of this fact, investigations aiming to obtain natural andor synthetic compounds possessing hepatoprotective activity have been undertaken. Review of plants with hepatoprotective activity evaluated in mexico. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Hepatoprotective activity of aerial parts of otostegia persica against. The liver is indeed the main organ involved in metabolism. Hepatoprotective activity of chhitchanthan extract powder against carbon tetrachlorideinduced liver injury in rats. The effects observed were compared with a known hepatoprotective agent, silymarin. Thus the antioxidant activity of the ethanolic extract may be due to the presence of flavonoid and phenolic compounds. Two novel trinorlanostanes, cochlates a and b 1 and 2, with a 3,4seco9,10seco9,19cyclo skeleton, as well as six new triterpenoids, fornicatins df 35 and ganodercochlearins ac 68, together with five known triterpenoids 9, were obtained from the fruiting bodies of ganoderma cochlear. The hepatoprotective activity of the methanol extract was assessed in paracetamol induced hepatotoxic rats. This is opposite to hepatotoxicity hepatoprotective molecules used in emergency medicine. Models of hepatoprotective activity assessment medicina.
Willd polygalaceae was lnvesti gated for its hepatoprotective activity in male wistar rats. These systems measures the ability of the test drugs to prevent or cure liver toxicity induced by various hepatotoxins in experimental animals. Phytochemical studies and hepatoprotective activity of melia azedarach linn, against ccl 4 induced hepatotoxicity in rats mohammed fazil ahmed1, a. To investigate the hepatoprotective activity of methanolic leaf extract of cyathea gigantea c.
Evaluation of hepatoprotective activity of aqeous leaf. Manokaran s, jaswanth a, sengottuvelu s, nandhakumar j, duraisamy r, karthikeyan d, et al. Phytochemical studies and hepatoprotective activity of. Coldenia procumbens linn, isoniazid, pyrazinamide, rifampicin, mtt assay. Its hepatoprotective activity is attributed to its antioxidant properties. Hepatoprotective effect of silymarin pubmed central pmc. Melia azedarach, hepatoprotective activity, simvastatin, ethanol and silymarin. The aim of the study is to investigate the phytochemicals and hepatoprotective activity of melia azedarach l leaves extracts against carbon tetrachloride ccl 4 induced hepatotoxicity. Sai sruthi arige, sai datri arige and lakshmana rao, a. It is a nontoxic hepatoprotective substance from the himalaya drug co. Original article hepatoprotective activity of pien tze. Antioxidant and hepatoprotective activity of the aqueous. Pdf hepatoprotective activity of some plants extract. Investigation of hepatoprotective activity of cyathea gigantea wall.
Alteration in the levels of biochemical markers of hepatic damage like sgot, sgpt, alp. Hepatoprotective activity of hepaxa polyherbal formulation ncbi. Hepatoprotective activity of ocimum sanctum alcoholic leaf extract. Here, we designed the experiments to examine the hepatoprotective activity of methanolic extract of leaves from underutilized c. Alteration in the levels of biochemical markers of hepatic damage like sgot. The aim of the study is to investigate the hepatoprotective activity of melia azedarach. We wanted to evaluate the hepatoprotective activity. In acute toxicity studies, the extract when administered to mice as a single i. Shristi badhani, shivani sharma, amrita kainth, bharat parashar department of pharmacy, manav bharti university, solan, h. Hepg2 cells showed significant dose dependent increase in percentage viability at the doses 20, 40, 60, 80 and 100 gml of cpre compared to ccl 4 exposed hepg2 cells. Antioxidants free fulltext hepatoprotective effect of. Antioxidant and hepatoprotective activity of garlic chives.
Amole tuber, cochlospermum vitifolium, heterotheca inuloides. Invitro analyses such as phenolic and flavonoid contents, antioxidant activity were done using standard spectrophotometric method and invivo antioxidant activity. About 600 commercial herbal formulations with hepatoprotective activity are being sold all over the world. Hepatoprotective activity of ocimum sanctum alcoholic leaf.
The liver is indeed the main organ involved in metabolism and detoxification for the excretion of various endogenous and exogenous substances. The hepatoprotective activity of eeih might be attributed to the flavonoid compounds such as catechin 1, 3. Hepatoprotective activity of aqueousmethanol extract of. Evidently, it may be stated that flavonoids of terminalia arjuna stem bark have hepatoprotective effect against ccl4 induced hepatic damage. Pdf liver diseases are a major worldwide health problem, with high endemicity in developing countries. To evaluate the hepatoprotective effect and study the metabolic profile of the anthocyaninrich extract of h. Antioxidant and hepatoprotective activity of ethanol extract. Hepatoprotective effects of triterpenoids from ganoderma cochlear. Hala salah eldin, haidar abdal gadir, abdel wahab hassan. In vitro hepatoprotective activity of terminalia arjuna. The test material was found effective as hepatoprotective, through in vivo and histopathological studies. Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. Phytochemistry and hepatoprotective activity of aqueous. Significant hepatoprotective activity of ocimum sanctum was reported earlier against paracetamol, carbon tetrachloride and antitubercular druginduced hepatoxicity in albino rats.
The hepatoprotective activity of hsare was assessed 100mgkgd for 4 weeks by examining the hepatic, inflammatory, oxidative stress markers and performing a histopathological. Hepatoprotective activity of ethanol extract of conyza b. Hepatoprotective activity of melia azedarach leaf extract. On the other hand, andrographolide was found to weakly inhibit cyp3a4 activity 38. Around 170 phytoconstituents isolated from 110 plants belonging to 55 families have been reported to possess hepatoprotective activity. Hepatoprotective activity of the leaves of nyctanthes arbor. Hepatoprotective activity of chhitchanthan extract powder against. Evaluation of the hepatoprotective activity of fagonia cretica l. Hepatoprotective sesquiterpenes and rutinosides from.
Hepatoprotective effect of leaf extracts from citrus hystrix. In an attempt to further establish the pharmacological properties of bauhinia purpurea fabaceae, hepatoprotective potential of methanol extract of b. Some have been analyzed and scientifically validated for their potentials. Ahsan 4 1 department of pharmacology, mamc, new delhi, india. Evaluation of hepatoprotective activity of adansonia digitata. Hepatoprotective activity of chitosan nanocarriers loaded.
Antioxidant and hepatoprotective activity of ethanol extract of valeriana wallichii in ccl 4 treated rats s. Male albino rats weighing between 150 and 175 g were used as animal models. Dixit, neelesh malviya and vijay ambawatia department of pharmacognosy, smriti college of pharmaceutical education, dewas naka, indore, madhya pradesh 452010 india. Evaluation of the hepatoprotective activity of portulaca oleracea l. The effect of a crude extract of the aerial parts of artemisia vulgaris av.
Antioxidant activity and hepatoprotective effect of an. In vitro and in vivo hepatoprotective activity of cissampelos. On day15 the hepatoprotective and antioxidant effects of eat were. The full text of this article is available in pdf format. The study was designed to evaluate the hepatoprotective activity of p. The phytochemical screening was carried on the leaves extracts of melia azedarach revealed the presence of some active. Pdf article info abstract liver is one of the largest and most vital organs in human body and the chief site for intense metabolism and.
The structural elucidation was achieved by interpretation of spectroscopic data. Supporting information coumarin analogues from the citrus. The extract was found to be effective in shortening the. Evaluation of hepatoprotective activity of amoora rohituka. The methanol extract of the fruit pulp of adansonia digitata l. Hepatoprotective activity of solanum trilobatum linn. The chemical composition of six essential oils eos of thymus serrulatus and thymus schimperi from six localities in ethiopia, namely ofla, alamata, yilmana densa, tarmaber, butajira and bale was determined. Willd ms and its ethyl acetate and nhexane fractions in isoniazid. Antioxidant and hepatoprotective actions of medicinal herb. Cleome viscosa linn tickweed the hepatoprotective activity of the cleome viscosa linn capparidaceae extract was assessed in cci 4 induced hepatotoxic rats. Antioxidant and hepatoprotective activity of ethanolic. There is a lack of reliable hepatoprotective drugs in modern medicine to prevent and treat druginduced liver damage.
The hepatoprotective activity of frp and frae was assessed by measuring the activity of serum transaminases ast and alt. Metabolic profile and hepatoprotective activity of the. Hepatoprotective activity of the ethanolic extract of ficus. A recent update on hepatoprotective potential of herbal plant mohammad irfan ali1 and manoj kumar2 1school of sciences, suresh gyan vihar university, jaipur302017, rajasthan, india 2marine biotechnology laboratory, department of botany, university of delhi, north campus, india corresponding authoremail. Hepatoprotective activity of the chloroform extract of the shade dried aerial parts of solanum trilobatum linn. The animals were divided in to five groups of six animals each and maintained on standard the leaves of nyctanthes arbortristis were collected from diet and water, ad libitum. The antioxidant and hepatoprotective actions of terminalia catappa l. The hepatoprotective activity of conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. Hepatoprotective activity of ethanol extract of pavetta. Hepatoprotective activity of the lichen usnea ghattensis has been established in vitro verma et al. This study investigated the hepatoprotective effects of aqueous leaf extract of swietenia mahogany maliaceae in chronic alcoholinduced liver injury in rats. R siddhartha college of pharmaceutical sciences, vijayawada, andhra pradesh, india. Further isolation of the active principles responsible for its hepatoprotective activity is currently in progress within our laboratory.
S2 hplc chromatograph for compound 1 elsd, 24% ch 3 cnh 2 o fig. Hepatoprotective activity of methanolic extract of bauhinia. Hepatoprotective activity of hepax was studied against three experimentally induced hepatotoxicity models, namely, carbon tetrachloride ccl4, paracetamol. Hence, it was proposed to carry out a preliminary in vitro analysis of the hepato protective activity of the plant, which gave promising results. Green tulsi ocimum sanctum, belonging to family lamiaceae are used traditionally for their hepatoprotective effect. Sumalatha, suhani and padma, divya and pai, sreedhara kr and kotian, sushma r and kumar, nitesh and bhat, kumar mr 2016 hepatoprotective activity of aqueous extract of. Evaluation of hepatoprotective activity of aqeous leaf extract of swietenia mahogani maliaceae in chronic alcoholinduced liver injury in rats. The extract exhibited significant hepatoprotective activity. A recent update on hepatoprotective potential of herbal plant. A number of natural tablets show promising hepatoprotective activities in acute and chronic liver damage. These conditions can be cured with hepatoprotective agents. The ethanolic extract of the plant polygala elongata klein ex. In order to identify the molecular mechanism involved in the hepatoprotection of ifc305 in ccl 4induced cirrhosis in rats, we extended our studies to analyze the effect of the compound on the. Composition and hepatoprotective activity of essential.
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